Wake Forest School of Medicine has served the needs of persons with sickle cell disease for many decades. In 2004 the Wake Forest University Sickle Cell Center of Excellence was established, offering the only Comprehensive Sickle Cell Program in the region which continues to the present day. In 2011, David M.

Johns Hopkins Medicine, headquartered in Baltimore, Maryland, is a $6.5 billion integrated global health enterprise and one of the leading health care systems in the United States.

Duke University has a long history of being committed to improving the care of persons with sickle cell disease. The Duke University Comprehensive Sickle Cell Center was founded in the late 1970's by Dr. Wendell F. Rosse in order to provide the best possible comprehensive care to patients with sickle cell disease. Directed by Marilyn J. Telen, M.D., it continues to provide to both adults and children with comprehensive services, including medical care, social services, psychological support, education and genetic counseling. Dr.

Mount Sinai

Mount Sinai Medical Center has comprehensive adult and pediatric clinics that are dedicated exclusively to the care of patients with sickle cell disease. Approximately 300 adult patients rely on The Comprehensive Center for Sickle Cell Disease for their care. The Mount Sinai Sickle Cell Program's mission is to preserve and promote health, while maximizing quality of life. The program is directed by Dr. Caroline Cromwell.